|
KMID : 0614020060210010050
|
|
Journal of Pharmaceutical Sciences (C.N.U.)
2006 Volume.21 No. 1 p.50 ~ p.53
|
|
|
Bioavailability Study of Nimodipine in Korean Volunteers
|
|
Kang Won-Ho
Shim Hee-Ok
Nam Jin-Kyung
Kim Dong-Chool
|
|
|
Abstract
|
|
|
|
A reversed phase HPLC method was developed and validated for the determination of nimodipine in human plasma. Nitrendipine was used as an internal standard. Calibration curves were linear in the concentration range of 5~300 ng/ml. The coefficient of variation of the intra- and inter-day precision was below 15%. The coefficient of variation of the accuracy was below 15% in the concentration range investigated. A bioavailability study was performed using the validated HPLC method. Eight healthy male volunteers were orally administered 30 mg of nimodipine. The pharmacokinetic parameters were calculated using WinNonlin. The mean values of AUC_(24hr) was 64.0±31.3 ng·hr/ml, C_(max) was 46.5±31.2 ng/ml, T_(max) was 0.54±0.17 hr and t_(1/2) was 3.03±2.26 hr. The pharmacokinetic parameters and the HPLC method can be used for the design of bioequivalence study of nimodipine.
|
|
|
KEYWORD
|
|
|
nimodipine nitrendipine, bioavailability, bioequivalence
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|